Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet
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چکیده
منابع مشابه
Maternal overnutrition impacts offspring adiposity and brain appetite markers-modulation by postweaning diet.
Maternal obesity has long-term consequences for the development of hypothalamic neurones involved in energy homeostasis and the metabolic profile in offspring. In the present study, we compared the effects of maternal obesity induced by longstanding high-fat diet (HFD) with milder postnatal overfeeding during suckling induced by litter size reduction. Female Sprague-Dawley rats consumed chow (C...
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Perinatal exposure to a maternal "junk-food" diet has been demonstrated to increase the preference for palatable diets in adult offspring. We aimed to determine whether this increased preference could be attributed to changes in μ-opioid receptor expression within the mesolimbic reward pathway. We report here that mRNA expression of the μ-opioid receptor in the ventral tegmental area (VTA) at w...
متن کاملMaternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring.
Epidemiological data and results from animal studies indicate that imbalances in maternal nutrition impact the expression of metabolic disorders in the offspring. We tested the hypothesis that consumption of excess saturated fats during pregnancy and lactation contributes to adult metabolic dysfunction and that these disturbances can be further influenced by the postweaning diet. Adult male off...
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Maternal overnutrition or associated complications putatively mediate the obesogenic effects of perinatal high-fat diet on developing offspring. Here, we tested the hypothesis that a Western diet developmental environment increases adiposity not only in male offspring from obesity-prone (DIO) mothers, but also in those from obesity-resistant (DR) dams, implicating a deleterious role for the Wes...
متن کاملMaternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism.
Maternal obesity is increasing, and it is known that the intrauterine experience programs fetal and newborn metabolism. However, the relative contributions of pre- or postnatal factors are unknown. We hypothesized that maternal overnutrition caused by long-term maternal obesity would exert a stronger detrimental impact than postnatal overnutrition on offspring metabolic homeostasis, with additi...
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ژورنال
عنوان ژورنال: Journal of Neuroendocrinology
سال: 2010
ISSN: 0953-8194,1365-2826
DOI: 10.1111/j.1365-2826.2010.02005.x